Coenzyme Q10 and rikkunshito prevent age-related changes in mouse otolith morphology and function

revealed that the RKT group had a significantly smaller volume of the 3 dimensional utriclar CT model (male mice; p = 0.0281, Steel test) and a significantly higher utricular CT number (male mice; p = 0.0104, Dunnett test) than the control group. The RKT group had a significantly weaker LVOR (male mice; lateral 1.3G stimulation; p = 0.00681, Dunnett test) (male mice; longitudinal 1.3G stimulation; p = 0.0183, Dunnett test) (male mice; longitudinal 0.7G stimulation; p = 0.00322, Dunnett test) than the control group. The CoQ10 group exhibited a significantly stronger utricle-induced LVOR than the control group (female mice; lateral 0.7G stimulation; p = 0.0133, Steel test).In conclusion, RKT prevented age-related utricular morphological changes, but did not prevent age-related otolith functional changes in male mice. CoQ10 prevented age-related utricular functional changes for low frequency stimulation in female mice.