LncRNA PVT1 activated by TGF-β1/Smad3 facilitates proliferation and metastasis of hepatocellular carcinoma via upregulating Smad6 and NRG1
This study validated that PVT1 activated by TGF-β1/Smad3 facilitates HCC progression and metastasis by upregulating the miR-186-5p/Smad6 and miR-143-3p/NRG1 axes, indicating its potential as a biological target for treating HCC.
Authors
- Kunlei Wang (ORCID: https://orcid.org/0000-0001-6459-2699)
- Zhi‐Nan Chen (ORCID: https://orcid.org/0000-0001-5512-4623)
- Shengyu Wu (ORCID: https://orcid.org/0000-0001-8411-8302)
- Yang Shi (ORCID: https://orcid.org/0000-0001-9713-1709)
- Xinyin Li
- Zhiyong Yang (ORCID: https://orcid.org/0000-0002-5430-5024)
- Bo Liao (ORCID: https://orcid.org/0000-0001-9770-5565)
- Zhixiang Cheng (ORCID: https://orcid.org/0000-0003-0867-685X)
- Ping Jiang (ORCID: https://orcid.org/0000-0001-9953-6443)
- Qian Cheng (ORCID: https://orcid.org/0000-0002-3674-1025)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s12967-025-06229-4
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Zhongnan Hospital of Wuhan University