Scoping Review of Paediatric Population Pharmacokinetic Models of Morphine
Several population pharmacokinetic models of morphine and its metabolites in paediatrics have been published across diverse patient groups. Bodyweight and age-related covariates emerged as the most common factors affecting clearance and distribution; other covariates, including mechanical ventilation, therapeutic cooling, and genetic variation, also impacted morphine pharmacokinetics. Further research should focus on validating the predictive accuracy of paediatric morphine models in different patient populations and the combined effect of covariates, such as those related to critical illness and genetic variation, on morphine pharmacokinetics.
Authors
- Marino S. Festa (ORCID: https://orcid.org/0000-0001-6541-7841)
- SOPHIE LENA STOCKER (ORCID: https://orcid.org/0000-0002-2114-587X)
- Indy Sandaradura (ORCID: https://orcid.org/0000-0002-9457-8262)
- M. Stokes (ORCID: https://orcid.org/0009-0005-6615-4998)
- Noha A Kamel
Institutions
- The University of Sydney (AU)
- Mansoura University (EG)
- Children's Hospital at Westmead (AU)
- Westmead Hospital (AU)
- St Vincent's Hospital Sydney (AU)
- St Vincent’s Private Hospital Sydney (AU)
- Institute for Musculoskeletal Health (AU)
- St Vincent's Clinic (AU)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1007/s40262-025-01477-5
- Citations
- 2
- Primary Topic
- Pediatric Pain Management Techniques
- Type
- article
- Field-Weighted Citation Impact
- 6.99
Funders
- University of Sydney