Deep Learning Model of Primary Tumor and Metastatic Cervical Lymph Nodes From CT for Outcome Predictions in Oropharyngeal Cancer
This prognostic study of p16+ OPSCC describes the development of a CT-based imaging risk score integrating PT and metastatic cervical LN features to predict recurrence risk and identify suitable candidates for treatment tailoring. This tool could optimize treatment modulations of p16+ OPSCC at a highly granular level.
Authors
- Shlomo A. Koyfman (ORCID: https://orcid.org/0000-0002-2275-5346)
- Kailin Yang (ORCID: https://orcid.org/0000-0001-5968-6738)
- Jonathan Lee (ORCID: https://orcid.org/0000-0002-5955-5145)
- Mihir R. Patel (ORCID: https://orcid.org/0000-0001-6477-9728)
- Tanmoy Dam (ORCID: https://orcid.org/0000-0003-3022-0971)
- Amaury Leroy (ORCID: https://orcid.org/0000-0001-5726-4232)
- Xiao T. Li (ORCID: https://orcid.org/0000-0002-1462-7272)
- Nabil F. Saba (ORCID: https://orcid.org/0000-0003-4972-1477)
- Krunal Pandav (ORCID: https://orcid.org/0000-0002-5451-7115)
- Sirvan Khalighi (ORCID: https://orcid.org/0000-0002-5563-1446)
- Sarah J. Stock (ORCID: https://orcid.org/0000-0003-4308-856X)
- J.O. Sonuga
- Pingfu Fu (ORCID: https://orcid.org/0000-0002-2334-5218)
- Bolin Song (ORCID: https://orcid.org/0009-0005-6108-4695)
Institutions
- University of Iowa (US)
- Georgia Institute of Technology (US)
- Cleveland Clinic (US)
- Veterans Health Administration (US)
- Emory University Hospital (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- Piedmont Cancer Institute (US)
- Winship Cancer Institute
- Case Western Reserve University (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.8094
- Citations
- 5
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 6.80
Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- Bristol-Myers Squibb
- Eli Lilly and Company
- AstraZeneca
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Cancer Institute
- DOD Prostate Cancer Research Program
- DOD Peer Reviewed Cancer Research Program