Nicotinamide N-Methyltransferase in the Inflammatory Pathogenesis of Graves’ Orbitopathy
Our results demonstrate that NNMT was associated with the inflammatory mechanisms of GO. Inhibiting NNMT, either through mRNA silencing or pharmacologic antagonism, markedly reduced pro-inflammatory reactions. These findings suggest that targeting NNMT is a promising therapeutic strategy for managing inflammation in GO.
Authors
- Dayoon Cho
- JaeSang Ko (ORCID: https://orcid.org/0000-0002-3011-7213)
- Jin Sook Yoon (ORCID: https://orcid.org/0000-0002-8751-9467)
- Soo Hyun Choi (ORCID: https://orcid.org/0000-0003-1421-5283)
Institutions
- Yonsei University (KR)
- Severance Hospital (KR)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1167/iovs.66.5.3
- Citations
- 4
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- National Research Foundation
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea