Antifungal susceptibility of a collection of Aspergillus fumigatus strains isolated from patients with invasive pulmonary aspergillosis and COVID-19 associated aspergillosis
We assessed the antifungal susceptibility of 86 Aspergillus fumigatus strains by a phenotypic test. Azole sensitivity was compared to a molecular test detecting cyp51A mutations. Azole resistance was quite limited, whereas strains from COVID-19 patients showed higher amphotericin B MICs. The molecular test showed a 100 %-agreement with the phenotypic assay.
Authors
- Giulia Lombardi (ORCID: https://orcid.org/0000-0001-6423-8358)
- Tiziana Lazzarotto (ORCID: https://orcid.org/0000-0003-3093-363X)
- Donatella Lombardo (ORCID: https://orcid.org/0000-0003-0730-742X)
- Andrea Liberatore (ORCID: https://orcid.org/0000-0002-6755-1937)
- Claudio Foschi (ORCID: https://orcid.org/0000-0001-7253-8799)
- Simone Ambretti (ORCID: https://orcid.org/0000-0002-8358-339X)
Institutions
- Azienda USL di Bologna (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Diagnostic Microbiology and Infectious Disease
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.diagmicrobio.2025.116884
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00