Altered blood–brain barrier permeability is associated with abnormal distant connectivity and regional homogeneity in covert hepatic encephalopathy—A cross-sectional study
There was a strong association between disrupted blood-brain barrier integrity and attenuated functional connectivity, with reductions in functional connectivity within the DMN and Frontoparietal Network (FPN), circuits closely linked to executive control. This attenuation was evident both in local regional and in distant connectivity within these networks.
Authors
- Joga Chaganti (ORCID: https://orcid.org/0000-0003-4776-5038)
- Bruce J. Brew (ORCID: https://orcid.org/0000-0003-0622-1392)
- Ian Lockart (ORCID: https://orcid.org/0000-0003-3031-5655)
- Mark Danta (ORCID: https://orcid.org/0000-0001-5551-6811)
- Sara Montagnese (ORCID: https://orcid.org/0000-0003-2800-9923)
- Amey Patil (ORCID: https://orcid.org/0000-0002-2563-8508)
- Georgia Zeng (ORCID: https://orcid.org/0000-0002-5459-4284)
- Michelle Dellalana (ORCID: https://orcid.org/0000-0002-5055-7574)
Institutions
- University of Padua (IT)
- Thomas Jefferson University Hospital (US)
- University of Surrey (GB)
- UNSW Sydney (AU)
- St Vincent's Hospital Sydney (AU)
- St Vincent's Health (AU)
- St Vincent's Clinic (AU)
- Imaging Center (US)
- St Vincents Institute of Medical Research (AU)
- The University of Notre Dame Australia (AU)
Publication Details
- Journal
- Hepatology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1097/hep.0000000000001343
- Citations
- 5
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 6.61