Metabolic correlations between kidney and eye in a mouse model of oxygen-induced retinopathy and retinopathy of prematurity
The presence of renal injury-related indicators may assist in diagnosing retinal neovascular diseases such as ROP. Arginine biosynthesis is the best common pathway of kidney-untargeted OIR metabolomics, vitreous- and retina-targeted OIR metabolomics and blood-targeted metabolomics of ROP, indicating that arginine biosynthesis might be the common pathway of ROP and neonatal kidney injury.
Authors
- Xiaoyan Chai
- Hetian Lei (ORCID: https://orcid.org/0000-0003-4091-1936)
- Yulin Zhang (ORCID: https://orcid.org/0000-0003-1828-1077)
- Zixin Fan (ORCID: https://orcid.org/0000-0003-4952-8917)
- Yinsheng Zhang (ORCID: https://orcid.org/0000-0003-4971-8809)
- Dongting Wu (ORCID: https://orcid.org/0000-0002-3463-2888)
- Xiaofeng Lu (ORCID: https://orcid.org/0009-0006-6164-8574)
- Hui Qi
- Guoming Zhang (ORCID: https://orcid.org/0000-0003-2123-8125)
- Lijun Dong (ORCID: https://orcid.org/0000-0003-2567-1065)
- Jie Sun
- Yuhang Yang (ORCID: https://orcid.org/0000-0001-9046-1561)
Institutions
- Jinan University (CN)
- Shantou University (CN)
- Shantou University Medical College (CN)
- Southern Medical University Shenzhen Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Zhejiang Gongshang University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- BMJ Open Ophthalmology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1136/bmjophth-2024-001955
- Citations
- 1
- Primary Topic
- Retinopathy of Prematurity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Natural Science Foundation of China
- Sanming Project of Medicine in Shenzhen
- Shenzhen Science and Technology Innovation Program
- Basic and Applied Basic Research Foundation of Guangdong Province