Retinal cell death is primarily caspase-dependent in vitro and in a mouse model of chloroquine-induced acute retinal toxicity
ARPE-19 cells underwent both apoptotic and pyroptotic cell death while 661W cells showed activation of apoptosis and necroptosis. Chloroquine-injected mice demonstrated characteristic phenotypes also observed in human patients with chloroquine toxicity and showed activation of various cell death mediators. By elucidating the mechanism of chloroquine toxicity, we believe our findings can shed light on potential therapeutic agents.
Authors
- Leslie Ramos (ORCID: https://orcid.org/0000-0003-4814-3417)
- Brandon V. Duffy (ORCID: https://orcid.org/0000-0002-2049-2781)
- Leo A. Kim (ORCID: https://orcid.org/0000-0001-9106-6416)
- Dhanesh Amarnani (ORCID: https://orcid.org/0000-0002-0678-768X)
- Eric J. Kim (ORCID: https://orcid.org/0000-0001-7771-4843)
Institutions
- Massachusetts Eye and Ear Infirmary (US)
Publication Details
- Journal
- ScienceBank
- Published
- 2025-05-01
- DOI
- https://doi.org/10.61340/rcdpcd
- Primary Topic
- Drug-Induced Ocular Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Massachusetts Lions Eye Research Fund
- National Institutes of Health
- National Eye Institute