Features of Invasive Aspergillosis Caused by <i>Aspergillus flavus</i>, France, 2012–2018
Invasive aspergillosis (IA) caused by Aspergillus flavus remains poorly described. We retrospectively analyzed 54 cases of IA caused by A. flavus reported in France during 2012-2018. Among cases, underlying IA risk factors were malignancy, solid organ transplantation, and diabetes. Most (87%, 47/54) infections were localized, of which 33 were pleuropulmonary and 13 were ear-nose-throat (ENT) infection sites. Malignancy (70% [23/33]) and solid organ transplantation (21% [7/33]) were the main risk factors in localized pulmonary infections, and diabetes mellitus was associated with localized ENT involvement (61.5%, [8/13]). Fungal co-infections were frequent in pulmonary (36%, 12/33) but not ENT IA (0 cases). Antifungal monotherapy was prescribed in 45/50 (90%) cases, mainly voriconazole (67%, 30/45). All-cause 30-day case-fatality rates were 39.2% and 90-day rates were 47.1%, and rates varied according to risk factor, IA site, and fungal co-infections. Clinicians should remain vigilant for A. flavus and consider it in the differential diagnosis for IA.
Authors
- Nicole Desbois-Nogard (ORCID: https://orcid.org/0000-0003-2384-5797)
- Milène Sasso (ORCID: https://orcid.org/0000-0002-6539-8545)
- Élisabeth Chachaty (ORCID: https://orcid.org/0000-0001-7916-7660)
- Olivier Paccoud (ORCID: https://orcid.org/0000-0002-3975-3136)
- Marc Pihet (ORCID: https://orcid.org/0000-0002-5955-058X)
- Karine Boukris-Sitbon
- Julie Bonhomme (ORCID: https://orcid.org/0000-0002-6635-6232)
- Guillaume Désoubeaux (ORCID: https://orcid.org/0000-0001-7945-9890)
- Jean‐Pierre Gangneux (ORCID: https://orcid.org/0000-0002-4974-5607)
- Marie-Fleur Durieux (ORCID: https://orcid.org/0000-0003-0784-9608)
- Blandine Denis (ORCID: https://orcid.org/0000-0003-2101-2601)
- Sophie Cassaing (ORCID: https://orcid.org/0000-0003-0055-0136)
- Raoul Herbrecht (ORCID: https://orcid.org/0000-0002-9381-4876)
- Stéphane Bretagne
- Fanny Lanternier (ORCID: https://orcid.org/0000-0003-3800-4683)
- Alexandre Alanio (ORCID: https://orcid.org/0000-0001-9726-3082)
- Dea Garcia‐Hermoso (ORCID: https://orcid.org/0000-0001-5288-2904)
- Céline Nourrisson (ORCID: https://orcid.org/0000-0002-4003-805X)
- Maud Gits‐Muselli (ORCID: https://orcid.org/0000-0002-0470-6866)
- Taïeb Chouaki (ORCID: https://orcid.org/0009-0002-3453-1232)
- François Danion (ORCID: https://orcid.org/0000-0003-3907-0658)
- Florent Morio
- Valérie Letscher‐Bru
- Lise Bertin-Biasutto
Institutions
- Hôpital Necker-Enfants Malades (FR)
- Institut Pasteur (FR)
- Université de Montpellier (FR)
- Université Paris Cité (FR)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Institut de Cancérologie Strasbourg (FR)
- Sorbonne Paris Cité (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Bretonneau (FR)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Centre Hospitalier Universitaire d'Angers (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Centre Hospitalier Universitaire de Martinique (MQ)
- Hôpital Saint-Louis (FR)
- Hôpitaux Universitaires de Strasbourg (FR)
- Centre Hospitalier Universitaire de Rennes (FR)
- Université de Rennes (FR)
- Université de Limoges (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Emerging infectious diseases
- Published
- 2025-05-01
- DOI
- https://doi.org/10.3201/eid3105.241392
- Citations
- 3
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 4.19