Matrix Stiffness Regulates the Osteogenic Differentiation of hPDLSCs via DNA Methylation
Matrix stiffness is positively associated with global DNA methylation, with DNMT3B likely mediating this regulation in hPDLSCs. Furthermore, DNA methylation levels are positively linked to the osteogenic capability of hPDLSCs.
Authors
- Shuli Cheng
- Rundong Ding
- Siyu He (ORCID: https://orcid.org/0000-0003-1137-2291)
- Rui Zou
- Zhen Chai (ORCID: https://orcid.org/0000-0003-1522-7710)
- Lingling Wang (ORCID: https://orcid.org/0000-0003-0272-2974)
- Qianqian Zhang (ORCID: https://orcid.org/0000-0002-0735-451X)
- Chen Chen
- Yijie Wang (ORCID: https://orcid.org/0000-0002-7433-3567)
Institutions
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- International Dental Journal
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.identj.2025.02.022
- Citations
- 7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China
- Natural Science Basic Research Program of Shaanxi Province