THE INFLUENCE OF SALIVARY GLYCOPROTEINS ON INDICATORS OF DENTAL PLAQUE FORMATION IN SCHOOLCHILDREN

Subject. The study of salivary sialoglycoprotein fractions, the activity of sialidase and salivary lysozyme in schoolchildren of key age groups at different risks of developing dental caries. Objectives. To evaluate changes in the composition of salivary sialoglycoproteins (protein-bound sialic acids, oligo-bound sialic acids, and free sialic acids) and their effect on dental plaque formation in children depending on the risk level of developing tooth decay, and also on the physicochemical and immunobiological properties of the oral fluid. Methodology. Participation in the study was based on voluntary informed consent. We conducted a prospective examination of 12-year-old students at a secondary school in the city of Teikovo, Ivanovo region. A comprehensive dental examination included the examination of the oral fluid in children with different risks of developing dental caries (minimal, moderate, and high): the rate of saliva production, the surface tension of saliva, acid-base potential of saliva, salivary lysozyme activity and sialidase activity. Results. We have obtained data on the composition of sialoglycoproteins and their effect on dental plaque formation processes in children of this age group at different risks of developing tooth decay. Conclusions. The composition of salivary glycoproteins depends on the risk level of developing dental caries in children and correlates with the processes of dental plaque formation (according to the PFRI index). The effect on sialoglycoproteins and the regulation of rheological properties of saliva is one of the pathogenetic mechanisms for the prevention of dental caries in children.