EFFECT OF BONE MORPHOGENETIC PROTEIN COATING 2 ON THE SURFACE OF A DENTAL IMPLANT ON ITS OSTEOGENESIS

One of the urgent tasks of modern dentistry is to solve the problem of optimal osseointegration of a dental implant – a strong structural and functional connection between the implant surface and bone tissue, which is a crucial factor for ensuring positive long-term results of orthopedic treatment. It is known that implantation prosthetics is associated with a fairly wide range of risks, including the possibility of implant rejection. The modern clinical community has proposed a fairly wide range of approaches to the prevention and treatment of osteogenesis disorders as a predictive measure to achieve optimal, including long-term results of dental implantation: the implementation of antiresorption and osteoanabolic therapy, the local use of growth factors and morphogenetic bone proteins as modifying components. The article is devoted to the study of the effect of coating with bone morphogenetic protein 2 (BMP2) on the surface of a dental implant on its osteogenesis. The authors substantiate the relevance and significance of the research topic. Modern methods of biological (biochemical) modification of the surface of dental implants are considered. A review of the literature and an analysis of the experience gained in international preclinical and clinical practice in the field of BMP2 application as a component of osteoinductive materials is carried out. The data on the effect of the BMP2 coating on the surface of a dental implant, including in combination with other bioactive components, on its osteogenesis are summarized. It is concluded that the use of VMR-2 in dentistry is relevant in order to increase the osteogenic potential of dental implantation in patients at risk with impaired bone metabolism, including mineral metabolism in the jawbones. It is pointed out that further in-depth research is needed to clarify the risk factors (side effects) associated with the use of BMP-2 and to develop optimal delivery systems for its long-term monitoring and accurate release of protein over time.