Enfortumab Vedotin-Induced Diabetic Ketoacidosis and Acute Tubulointerstitial Nephritis Requiring Intensive Care in the Treatment of Advanced Urothelial Carcinoma: A Case Report
Although the detailed mechanism that induced insulin resistance remains unclear, the patient required high-dose insulin because of a marked increase in insulin resistance. If hyperglycemia is observed during EV therapy, DKA may lead to the occurrence of serious AEs. We report on the pathogenesis and management of drug-induced DKA caused by EV based on our case and a literature review.
Authors
- Hiromichi Katayama (ORCID: https://orcid.org/0000-0001-8339-5164)
- Takuma Sato (ORCID: https://orcid.org/0000-0002-5555-7709)
- Akihiro Ito (ORCID: https://orcid.org/0000-0001-7224-1100)
- Tomonori Sato (ORCID: https://orcid.org/0000-0001-5659-6809)
- Naoki Kawamorita (ORCID: https://orcid.org/0000-0001-6175-3063)
- Yohei Satake (ORCID: https://orcid.org/0000-0003-3961-1004)
- Shinichi Yamashita (ORCID: https://orcid.org/0000-0003-3092-7715)
- Satoko Kurosawa
- Hideki Katagiri (ORCID: https://orcid.org/0000-0002-2786-8569)
- Yoshihide Kawasaki (ORCID: https://orcid.org/0000-0001-6425-3574)
- Ryo Matsui
- Kei Takahashi (ORCID: https://orcid.org/0000-0002-9853-3723)
Institutions
- Tohoku University (JP)
Publication Details
- Journal
- Case Reports in Oncology
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1159/000545957
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.35