Chelating-Group-Assisted C(sp<sup>2</sup>)–O Reductive Elimination at the Gold(III) Center
Herein, we demonstrate chelating-group-assisted C(sp<sup>2</sup>)-O reductive elimination at gold(III) centers. Detailed stoichiometric studies highlighted the importance of a chelating group for achieving successful C-O reductive elimination, paving the way for the development of a catalytic version. The mechanistic investigations, including control experiments, <sup>31</sup>P NMR, mass spectrometry, and density functional theory (DFT) studies, suggested that the synergistic effect of the ligand and chelating group creates a highly coordinated environment around the Au(III) center to facilitate the C(sp<sup>2</sup>)-O bond-forming reaction.
Authors
- Nitin T. Patil (ORCID: https://orcid.org/0000-0002-8372-2759)
- Avishek Das (ORCID: https://orcid.org/0000-0003-2861-7996)
- Sadhana Tripathi (ORCID: https://orcid.org/0009-0005-1046-7653)
- Lisa Roy (ORCID: https://orcid.org/0000-0003-4205-1626)
Institutions
- Indian Institute of Technology Kharagpur (IN)
- Indian Institute of Science Education and Research, Bhopal (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1021/acs.orglett.5c01053
- Citations
- 6
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Council of Scientific and Industrial Research, India
- Indian Institute of Science Education and Research Bhopal
- Science and Engineering Research Board