Bovine collagen peptides and peptide–calcium complexes inhibit <scp>RANKL</scp>‐induced osteoclast differentiation in <scp>RAW</scp> 264.7 macrophages
HBPs and HBPs-Ca demonstrated stronger activity in inhibiting osteoclast formation compared to BPs and BPs-Ca. This enhanced activity is likely due to structural changes in the peptides caused by heat treatment, which increase their antioxidant properties and antagonistic effects on RANKL. These findings indicate that bovine collagen peptides and their calcium chelates can inhibit the formation of osteoclasts by activating the NF-κB pathway, thereby influencing bone metabolism and providing a theoretical basis for the treatment of osteoporosis. © 2025 Society of Chemical Industry.
Authors
- Yixin Zhao (ORCID: https://orcid.org/0000-0002-7856-2818)
- Yi‐Tao Yu (ORCID: https://orcid.org/0000-0003-2368-2799)
- Jin Wang (ORCID: https://orcid.org/0009-0009-9516-4756)
- Yue Zhu
- Yuanyi Liu (ORCID: https://orcid.org/0009-0009-8456-0761)
- Guofeng Jin (ORCID: https://orcid.org/0000-0002-3592-222X)
- Jin Zhu
Institutions
- Beijing Technology and Business University (CN)
Publication Details
- Journal
- Journal of the Science of Food and Agriculture
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/jsfa.14308
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Beijing Technology and Business University