All‐Cause Acute Illness Hospitalisations in the Preceding Two Years Are Associated With Cognitive Decline in Older Adults: The Sydney Memory and Ageing Study
This study confirms and adds nuance to international findings that overnight hospitalization is associated with accelerated cognitive decline. This association was dose-dependent, had a recency effect and was independent of illness severity in the case of cLOS. These findings suggest that all-cause acute hospitalization may be a reversible risk factor for cognitive decline. This needs further clarification and the development of interventions to minimise the impact of acute illness hospitalization on cognitive trajectory. To this end, broadening the scope of acute care in the home and the prevention and treatment of neuroinflammation are priorities for further investigation.
Authors
- Lucia Chinnappa‐Quinn (ORCID: https://orcid.org/0000-0003-3300-1678)
- Nicole A. Kochan (ORCID: https://orcid.org/0000-0002-8630-6398)
- Steve R. Makkar (ORCID: https://orcid.org/0000-0003-2403-2472)
- Henry Brodaty (ORCID: https://orcid.org/0000-0001-9487-6617)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Lara Harvey (ORCID: https://orcid.org/0000-0001-6260-8001)
- Ben C. P. Lam (ORCID: https://orcid.org/0000-0002-0879-5990)
- John D. Crawford
Institutions
- La Trobe University (AU)
- UNSW Sydney (AU)
- Eastern Health (AU)
- Prince of Wales Hospital (AU)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- International Journal of Geriatric Psychiatry
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/gps.70077
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Society of Anaesthetists
- University of New South Wales
- NSW Ministry of Health
- Medical Research Council
- National Health and Medical Research Council