Lung-directed delivery of a ligand-mediated chimeric lysin has an enhanced ability to eradicate pulmonary and intracellular Staphylococcus aureus
The lung-directed peptide-fused ClyC (p-ClyC) is a novel and effective lysin to be against intracellular S. aureus and a potential antimicrobial agent for therapeutics against the pulmonary infections by S. aureus.
Authors
- Dongyan Xiong
- Junping Yu (ORCID: https://orcid.org/0000-0001-9024-0793)
- Heng Xue
- Min Chen (ORCID: https://orcid.org/0000-0001-5761-3981)
- Hongping Wei (ORCID: https://orcid.org/0000-0002-9948-8880)
- Xiaoxu Zhang (ORCID: https://orcid.org/0000-0001-8758-9804)
- Xiaohong Li (ORCID: https://orcid.org/0000-0001-8164-5633)
Institutions
- Wuhan Institute of Virology (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s12866-025-03978-6
- Citations
- 2
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 2.37
Funders
- Chinese Academy of Sciences