Exploring the Active Ingredients and Core Targets of Erxia Decoction inthe Treatment of Sleep Disorder by Integration of Network Pharmacologyand Proteomics
This study preliminarily revealed EXD, morin (MOR) and quercetin (QUE) mainly inhibited the AKT1 core targets for the treatment of SLD using the network pharmacological analysis, proteomics, Western blotting, and molecular docking. The results elucidated partly the molecular mechanism and provided clues and a basis for further research.
Authors
- Hua Yang (ORCID: https://orcid.org/0000-0001-8594-5027)
- Fei Zhou
- Huihua Qu
- Xueqian Hu
- Zhanwen Liu (ORCID: https://orcid.org/0000-0002-9361-7151)
- Bo Jiang (ORCID: https://orcid.org/0000-0002-9399-9065)
Institutions
- Tongji University (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-04-29
- DOI
- https://doi.org/10.2174/0113862073348555250320035548
- Citations
- 1
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.84