Esketamine Reduces Lung Injury Caused by Limb Ischemia-Reperfusion by Regulating Oxidative Stress via the TLR4/NF-κB/NLRP3 Pathway

Esketamine protected against LIR-induced ALI by mitigating oxidative stress and suppressing the TLR4/NF-κB/NLRP3 axis. These findings highlight the potential therapeutic value of esketamine for ALI.

Authors

Meng Wang (ORCID: https://orcid.org/0000-0002-1202-3678)
Wen‐Juan Wang (ORCID: https://orcid.org/0000-0003-4879-3188)
Qian Ma (ORCID: https://orcid.org/0000-0002-3272-9723)
Heng Wen (ORCID: https://orcid.org/0000-0001-8925-7643)
Jiawei Cun

Institutions

Ningxia Medical University (CN)
First Affiliated Hospital Zhejiang University (CN)

Publication Details

Journal: Endocrine Metabolic & Immune Disorders - Drug Targets
Published: 2025-04-29
DOI: https://doi.org/10.2174/0118715303393744250423100211
Citations: 1
Primary Topic: Cardiac Ischemia and Reperfusion
Type: article
Field-Weighted Citation Impact: 1.47

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article

Esketamine Reduces Lung Injury Caused by Limb Ischemia-Reperfusion by Regulating Oxidative Stress via the TLR4/NF-κB/NLRP3 Pathway

Meng Wang, Wen‐Juan Wang, Qian Ma, Heng Wen et al.

Apr 29, 2025

1 citations

Endocrine Metabolic & Immune Disorders - Drug Targets

Cardiac Ischemia and Reperfusion

1.47

article

Esketamine Reduces Lung Injury Caused by Limb Ischemia-Reperfusion by Regulating Oxidative Stress via the TLR4/NF-κB/NLRP3 Pathway

Meng Wang, Wen‐Juan Wang, Qian Ma, Heng Wen, Jiawei Cun

April 29, 2025article en

1 citations

Abstract

Esketamine protected against LIR-induced ALI by mitigating oxidative stress and suppressing the TLR4/NF-κB/NLRP3 axis. These findings highlight the potential therapeutic value of esketamine for ALI.

Endocrine Metabolic & Immune Disorders - Drug TargetsVol. 25

Ningxia Medical University (CN), First Affiliated Hospital Zhejiang University (CN)

Openalex Percentile: Top 20%

Cardiac Ischemia and Reperfusion

1.47

DOI Source OpenAlex

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