Enhanced Apoptosis in Pancreatic Cancer Cells through Thymoquinone-rich Nigella sativa L. Methanol Extract: Targeting NRF2/HO-1 and TNF-α Pathways
The findings suggest that TM and TQ exhibit strong anticancer potential by modulating key signaling pathways in pancreatic cancer cells, supporting their potential for further development as therapeutic agents in pancreatic cancer treatment.
Authors
- İlknur Çınar Ayan (ORCID: https://orcid.org/0000-0002-8763-0480)
- Sümeyra Çetinkaya (ORCID: https://orcid.org/0000-0002-5811-8832)
- Mithat Atak
- Ipek Peşin Süntar (ORCID: https://orcid.org/0000-0003-4201-1325)
- Hasya Nazlı Gök (ORCID: https://orcid.org/0000-0003-4115-7509)
- Kevser Taban Akça (ORCID: https://orcid.org/0000-0001-8620-6402)
- Hatice Gül Dursun (ORCID: https://orcid.org/0000-0001-5115-4681)
Institutions
- Sivas Cumhuriyet Üniversitesi (TR)
- Biotechnology Research Center (IR)
- Necmettin Erbakan University (TR)
- Central Research Institute (IN)
- Field Crops Research Institute (VN)
- Gazi University (TR)
Publication Details
- Journal
- Anti-Cancer Agents in Medicinal Chemistry
- Published
- 2025-05-14
- DOI
- https://doi.org/10.2174/0118715206370057250421061226
- Citations
- 1
- Primary Topic
- Nigella sativa pharmacological applications
- Type
- article
- Field-Weighted Citation Impact
- 2.38