In Silico Identification of 2,4-Diaryl-6-styrylpyridine Derivatives as Orthosteric-allosteric EGFR Inhibitors

This study identified NASP06 and NASP01 as the most stable orthosteric and allosteric inhibitors of EGFR TK, respectively. These findings revealed a novel class of EGFR TK inhibitors capable of interacting with both orthosteric and allosteric sites.

Authors

Harno Dwi Pranowo (ORCID: https://orcid.org/0000-0002-0223-5036)
Jumina Jumina (ORCID: https://orcid.org/0000-0003-2604-7838)
Eti Nurwening Sholikhah (ORCID: https://orcid.org/0000-0002-6545-8691)
Harizal Harizal

Institutions

Universitas Gadjah Mada (ID)
Universitas Esa Unggul (ID)

Publication Details

Journal: Current Computer - Aided Drug Design
Published: 2025-04-29
DOI: https://doi.org/10.2174/0115734099370189250416024026
Primary Topic: Lung Cancer Treatments and Mutations
Type: article
Field-Weighted Citation Impact: 0.00

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article

In Silico Identification of 2,4-Diaryl-6-styrylpyridine Derivatives as Orthosteric-allosteric EGFR Inhibitors

Harno Dwi Pranowo, Jumina Jumina, Eti Nurwening Sholikhah, Harizal Harizal

Apr 29, 2025

Current Computer - Aided Drug Design

Lung Cancer Treatments and Mutations

article

In Silico Identification of 2,4-Diaryl-6-styrylpyridine Derivatives as Orthosteric-allosteric EGFR Inhibitors

Harno Dwi Pranowo, Jumina Jumina, Eti Nurwening Sholikhah, Harizal Harizal

April 29, 2025article en

Abstract

This study identified NASP06 and NASP01 as the most stable orthosteric and allosteric inhibitors of EGFR TK, respectively. These findings revealed a novel class of EGFR TK inhibitors capable of interacting with both orthosteric and allosteric sites.

Current Computer - Aided Drug DesignVol. 21

Universitas Gadjah Mada (ID), Universitas Esa Unggul (ID)

Openalex Percentile: Top 86%

Lung Cancer Treatments and Mutations

DOI Source OpenAlex

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