Current Organoid Culture Systems in Pancreatic Cancer
Despite advances in therapeutic regimens, Pancreatic Cancer (PC) still remains an aggressive malignancy characterized by high treatment resistance, mortality, and poor clinical outcome. Hence, there is an urgent need for more effective therapeutic methods to improve the survival of PC patients. Currently, organoid culture systems have emerged as a preclinical research model for studying cancer progression, biology, and treatment responses, bridging the translational gap between <i>in vivo</i> and <i>in vitro</i> models. This review summarized the common culture systems of PC organoids, paving the way for precision medicine in PC.
Authors
- Min Wang (ORCID: https://orcid.org/0000-0002-8618-1310)
- Lianyong Li (ORCID: https://orcid.org/0000-0002-0852-7005)
- Xuechan Tang
- Shuai Zhang (ORCID: https://orcid.org/0000-0003-0272-0856)
- Jing Sun (ORCID: https://orcid.org/0009-0002-6647-4738)
- Qian Yue (ORCID: https://orcid.org/0000-0002-2976-6240)
- Changqing Zhong (ORCID: https://orcid.org/0000-0002-4199-1272)
- Sheng Chen (ORCID: https://orcid.org/0009-0002-1201-3848)
- Lei Liu (ORCID: https://orcid.org/0009-0005-0463-2886)
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Current Topics in Medicinal Chemistry
- Published
- 2025-05-14
- DOI
- https://doi.org/10.2174/0115680266392238250423115420
- Citations
- 1
- Primary Topic
- Biological Research and Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81