Access to <i>N</i> ‐Monofluoromethylated (Thio)Carbamates, Formamides, Alkynamides, and Related Derivatives
This work presents the first general synthetic access to N-CH₂F and N-CHRF carbamates, thiocarbamates, formamides, alkynamides, and related compounds. The synthetic approach employs N-CH<sub>2</sub>F and N-CHRF carbamoyl fluorides as versatile strategic building blocks, which can be efficiently synthesized in a single step directly from readily available amines or imines.
Authors
- Franziska Schoenebeck (ORCID: https://orcid.org/0000-0003-0047-0929)
- Che-Ming Hsu (ORCID: https://orcid.org/0009-0003-1430-7943)
- Filip G. Zivkovic
- Fritz Bahns (ORCID: https://orcid.org/0009-0004-1445-1192)
Institutions
- RWTH Aachen University (DE)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/anie.202505478
- Citations
- 6
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 4.74
Funders
- RWTH Aachen University
- European Research Council