<scp>STAT3</scp> expression is reduced in cardiac pericytes in <scp>HFpEF</scp> and its loss reduces cellular adhesion and induces pericyte senescence

Heart failure with preserved ejection fraction (HFpEF) accounts for half of heart failure cases and is characterised by reduced pericyte coverage. While the contributions of other cardiac cell types to HFpEF are well-studied, the role of pericytes remains less understood. Using murine single-nucleus RNA-sequencing to study cardiac pericytes in HFpEF, we identified reduced STAT3 expression as a hallmark of HFpEF pericytes. Mechanistic studies in vitro revealed that STAT3 deletion induces cellular senescence and impairs pericyte adhesion, recapitulating HFpEF-like characteristics. These findings suggest that STAT3 is crucial for maintaining pericyte homeostasis and highlight its reduction as a potential driver of pericyte loss, a defining feature of HFpEF.

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Publication Details

Journal
FEBS Letters
Published
2025-05-01
DOI
https://doi.org/10.1002/1873-3468.70057
Primary Topic
Cardiac Fibrosis and Remodeling
Type
article
Field-Weighted Citation Impact
0.00

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article

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

Guillermo Luxán, Maximilian Merten, Stefanie Dimmeler, Dennis Hecker et al.
FEBS Letters
Cardiac Fibrosis and Remodeling
article

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

Guillermo Luxán, Maximilian Merten, Stefanie Dimmeler, Dennis Hecker, Jochen Wilhelm, Badder Kattih, Ariane Fischer, Anita Tamiato, Valentina O. Püntmann, David John, Felicitas Escher, Eike Nagel, Mariano Ruz Jurado, Marcel H. Schulz, Leah Rebecca Vanicek, Tara Procida‐Kowalski
article en

Abstract

Heart failure with preserved ejection fraction (HFpEF) accounts for half of heart failure cases and is characterised by reduced pericyte coverage. While the contributions of other cardiac cell types to HFpEF are well-studied, the role of pericytes remains less understood. Using murine single-nucleus RNA-sequencing to study cardiac pericytes in HFpEF, we identified reduced STAT3 expression as a hallmark of HFpEF pericytes. Mechanistic studies in vitro revealed that STAT3 deletion induces cellular senescence and impairs pericyte adhesion, recapitulating HFpEF-like characteristics. These findings suggest that STAT3 is crucial for maintaining pericyte homeostasis and highlight its reduction as a potential driver of pericyte loss, a defining feature of HFpEF.

FEBS LettersVol. 599(12)
Goethe University Frankfurt (DE), Justus-Liebig-Universität Gießen (DE), German Center for Lung Research (DE), Universities of Giessen and Marburg Lung Center (DE), University Hospital Frankfurt (DE), CS Diagnostics (DE), Cardio-Pulmonary Institute (DE)
Deutsches Zentrum für Herz-Kreislaufforschung, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Hessisches Ministerium für Wissenschaft und Kunst
Openalex Percentile: Top 84%
Cardiac Fibrosis and Remodeling
DOIOpen Access PDFOpenAlex
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