Head and neck squamous cell carcinoma-derived extracellular vesicles mediate Ca²⁺-dependent platelet activation and aggregation through tissue factor
These findings indicate a therapeutic potential of targeting EV-mediated pathways as a therapeutic approach to alleviate thrombotic complications in HNSCC patients. Subsequent animal studies will be crucial to validate and extend these observations, providing deeper insight into their clinical implications.
Authors
- Gabriele Multhoff (ORCID: https://orcid.org/0000-0002-2616-3137)
- Mina Yazdi
- Barbara Wollenberg (ORCID: https://orcid.org/0000-0002-3062-459X)
- Maria Shoykhet
- Benedikt Schmidl (ORCID: https://orcid.org/0000-0003-2201-4246)
- Julia Mergner (ORCID: https://orcid.org/0000-0002-4332-1280)
- Khouloud Hachani (ORCID: https://orcid.org/0000-0001-8424-3912)
- Omid Azimzadeh (ORCID: https://orcid.org/0000-0001-8984-0388)
- Ali Bashiri Dezfouli (ORCID: https://orcid.org/0009-0003-1412-5349)
- Cosima C. Hoch (ORCID: https://orcid.org/0000-0002-3875-7389)
- Marie‐Nicole Theodoraki (ORCID: https://orcid.org/0000-0002-5491-1593)
- Julie Petry
- Tobias Weiser
Institutions
- TUM Klinikum (DE)
- Federal Office for Radiation Protection (DE)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1186/s12964-025-02215-x
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Technische Universität München
- Universität Ulm