Porokeratosis of Mibelli affecting the lips: A novel ultraviolet-induced fluorescence dermoscopy finding

Porokeratoses represent a rare spectrum of keratinisation disorders that commonly present as annular, scaly plaques with an atrophic center and either hyper or hypopigmentation. They can be inherited in an autosomal dominant pattern with variable penetrance or occur sporadically. Porokeratosis of Mibelli (PM) is a solitary variant that usually presents in childhood or adolescence and has been attributed to immunosuppression, although the underlying mechanisms remain unclear. Importantly, PM is recognised as a potentially premalignant condition. Ultraviolet-induced fluorescence dermoscopy (UVFD) is a novel, emerging, non-invasive diagnostic tool that can assist in diagnosing various skin lesions. Herein, we report a case of PM affecting the lips, that revealed an unexpected finding on UVFD examination.

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Publication Details

Journal
Photodiagnosis and Photodynamic Therapy
Published
2025-05-01
DOI
https://doi.org/10.1016/j.pdpdt.2025.104617
Primary Topic
Genetic and rare skin diseases.
Type
article
Field-Weighted Citation Impact
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article

Porokeratosis of Mibelli affecting the lips: A novel ultraviolet-induced fluorescence dermoscopy finding

Adarshlata Singh, Bhushan Madke, H Varun
Photodiagnosis and Photodynamic Therapy
Genetic and rare skin diseases.
article

Porokeratosis of Mibelli affecting the lips: A novel ultraviolet-induced fluorescence dermoscopy finding

Adarshlata Singh, Bhushan Madke, H Varun
article en

Abstract

Porokeratoses represent a rare spectrum of keratinisation disorders that commonly present as annular, scaly plaques with an atrophic center and either hyper or hypopigmentation. They can be inherited in an autosomal dominant pattern with variable penetrance or occur sporadically. Porokeratosis of Mibelli (PM) is a solitary variant that usually presents in childhood or adolescence and has been attributed to immunosuppression, although the underlying mechanisms remain unclear. Importantly, PM is recognised as a potentially premalignant condition. Ultraviolet-induced fluorescence dermoscopy (UVFD) is a novel, emerging, non-invasive diagnostic tool that can assist in diagnosing various skin lesions. Herein, we report a case of PM affecting the lips, that revealed an unexpected finding on UVFD examination.

Photodiagnosis and Photodynamic TherapyVol. 53
Datta Meghe Institute of Higher Education and Research (IN)
Openalex Percentile: Top 89%
Genetic and rare skin diseases.
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