Follow-up of antibody changes in brucellosis patients in Gansu, China

<i>Brucella</i>, a zoonotic intracellular bacterium, poses significant threats to both human health and economic security. Clinically, brucellosis can be challenging to differentiate from other long-term febrile illnesses, necessitating prompt and standardized treatment to prevent chronic persistent infections and multi-organ damage, which are notoriously difficult to treat. Thus, gaining a comprehensive understanding of the disease's progression is essential for early diagnosis and effective treatment strategies. This paper delves into the dynamics of serum antibody titers in patients with acute brucellosis, shedding light on the temporal patterns of antibody titers. Such insights are pivotal for monitoring disease progression and assessing the efficacy of treatment interventions. Furthermore, through western blotting analysis, the study reveals that antibodies against the BP26 protein in brucellosis patients persist over an extended period, which is helpful to identify the durable immune response of brucellosis and provides a theoretical basis for vaccine development and treatment strategy formulation.