DUOX2 activation drives bacterial translocation and subclinical inflammation in IBD-associated dysbiosis
Elevated DUOX2 signalling contributes to epithelial barrier dysfunction, microbiome alterations and subclinical inflammation. Butyrate and HDAC inhibitors reversed these effects, indicating that DUOX2 may be a therapeutic target in IBD.
Authors
- Siobhan Proksell
- Fahong Yu (ORCID: https://orcid.org/0000-0002-9342-6419)
- David H. Kerman
- María T. Abreu (ORCID: https://orcid.org/0000-0002-7294-0574)
- Irina Fernández (ORCID: https://orcid.org/0000-0002-0184-0744)
- Maria A. Quintero (ORCID: https://orcid.org/0000-0003-2249-6564)
- Hajar Hazime (ORCID: https://orcid.org/0000-0002-9759-9034)
- Katerina M. Faust (ORCID: https://orcid.org/0000-0002-7277-5505)
- Eddy E. Gonzalez-Horta (ORCID: https://orcid.org/0000-0003-2043-7552)
- Judith Pignac-Kobinger (ORCID: https://orcid.org/0000-0001-5842-4488)
- Amar R. Deshpande (ORCID: https://orcid.org/0009-0007-0848-7158)
- Gloria Michelle Ducasa
- Christian Jobin (ORCID: https://orcid.org/0000-0002-3733-1001)
- Oriana M. Damas (ORCID: https://orcid.org/0000-0002-9256-190X)
- Nivis Brito
- Juan F. Burgueño
- Landon Wilson (ORCID: https://orcid.org/0000-0002-0246-6491)
- Raad Z. Gharaibeh (ORCID: https://orcid.org/0000-0001-5484-8902)
- Ana M. Santander (ORCID: https://orcid.org/0000-0003-1781-8549)
- Stephen Barnes (ORCID: https://orcid.org/0000-0001-7961-0837)
- Yanping Zhang (ORCID: https://orcid.org/0000-0002-1680-7592)
Institutions
- Cedars-Sinai Medical Center (US)
- University of Miami (US)
- University of Alabama at Birmingham (US)
- University of Florida (US)
Publication Details
- Journal
- Gut
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1136/gutjnl-2024-334346
- Citations
- 18
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 14.51
Funders
- National Institute of Diabetes and Digestive and Kidney Diseases