Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD
This integrated multimodel approach provides a framework for systematically assessing the molecular landscape of intestinal inflammation. Our findings reveal conserved inflammatory circuits, refine model selection, offering a valuable resource for the IBD research community.
Authors
- Christoph Becker (ORCID: https://orcid.org/0000-0002-1388-1041)
- Stefan Wirtz (ORCID: https://orcid.org/0000-0001-6936-7431)
- Kai Hildner (ORCID: https://orcid.org/0000-0001-5007-4874)
- Leonard Diemand
- Claudia Günther (ORCID: https://orcid.org/0000-0001-8360-3525)
- Elisabeth Naschberger (ORCID: https://orcid.org/0000-0003-1291-622X)
- Andreas Gießl (ORCID: https://orcid.org/0000-0002-9768-2049)
- Benno Weigmann (ORCID: https://orcid.org/0000-0002-2398-0844)
- Britta Siegmund (ORCID: https://orcid.org/0000-0002-0055-958X)
- Lena Erkert
- Markus F. Neurath (ORCID: https://orcid.org/0000-0003-4344-1474)
- Raja Atreya (ORCID: https://orcid.org/0000-0002-8556-8433)
- Christina Plattner (ORCID: https://orcid.org/0000-0002-3217-3278)
- Iris Stolzer
- Jay V. Patankar (ORCID: https://orcid.org/0000-0002-1884-7424)
- Roodline Cineus (ORCID: https://orcid.org/0000-0003-4393-5757)
- Martin Dinkel
- Laura Schickedanz
- Fabrizio Mascia
- Gregor Sturm (ORCID: https://orcid.org/0000-0001-9584-7842)
- Ahmed N. Hegazy (ORCID: https://orcid.org/0000-0002-2946-8251)
- Katharina Gerlach (ORCID: https://orcid.org/0000-0001-5855-7205)
- Miguel González-Acera (ORCID: https://orcid.org/0009-0008-9445-5650)
- Reyes Gámez‐Belmonte (ORCID: https://orcid.org/0000-0002-7159-8957)
- Kristina Koop (ORCID: https://orcid.org/0000-0002-1672-7234)
- Pooja Gupta (ORCID: https://orcid.org/0009-0009-3328-5157)
- Tamara Leupold (ORCID: https://orcid.org/0000-0002-2026-4340)
- Michael Stürzl (ORCID: https://orcid.org/0000-0002-9276-2824)
- Zlatko Trajanoski (ORCID: https://orcid.org/0000-0002-0636-7351)
- Marvin Bubeck (ORCID: https://orcid.org/0000-0001-6612-1989)
- Ru Wang
- Lili Bao
- Heidi Limberger
Institutions
- Innsbruck Medical University (AT)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universität Innsbruck (AT)
- Humboldt-Universität zu Berlin (DE)
- Universitätsklinikum Erlangen (DE)
- German Rheumatism Research Centre (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Gut
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1136/gutjnl-2024-333729
- Citations
- 4
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Deutsche Forschungsgemeinschaft
- Volkswagen Foundation