Comparison of Hemodynamic Changes with Fentanyl and Lignocaine as Adjuvant Agents during Induction of Anesthesia

Objective: To determine the influence of fentanyl and lignocaine on hemodynamic changes during induction of anesthesia. Study Design: Quasi-Experimental Study. Place and Duration of Study: Combined Military Hospital Rawalpindi, Pakistan from Feb to Aug 2021. Methodology: Patients of age range 35 - 55 years belonging to American Society of Anesthesiologists (ASA) group I, II, III undergoing elective surgeries under general anesthesia who gave informed written consent were included in the study. Under standardized general anesthesia Group-A (Fentanyl) received 04 micrograms/kg intravenous bolus of fentanyl and Group–B (Lignocaine) was administered 1.5mg/kg intravenous bolus of Lignocaine. The surgical stimulus was avoided during the first five minutes of post-intubation monitoring. Recorded variables were heart rate, diastolic and systolic blood pressure, before intubation and 1, 3, 5 minutes after intubation. Results: A total of 108 patients enrolled in the study out of which 53(49.07%) were males whereas 55(50.9%) were females with a mean age of 42.74±7.06 (35–55 years). Out of participants, 25(23.1%), 65(60.1%), and 18(16.66%) patients were from the American Society of Anesthesiologists status I, II, and III respectively. No significant relationship enumerated in heart rate (p-value 0.011) whereas systolic and diastolic blood pressure represented significant difference between two batches (p-value<0.001). Conclusion: Attenuation of hemodynamic response can be achieved with both intravenous bolus of fentanyl or lignocaine, however fentanyl has a more stable influence on the heart rate, and systolic and diastolic blood pressure when compared with lignocaine.