A case of idiosyncratic drug‐induced agranulocytosis because of sulbactam/ampicillin

Idiosyncratic drug-induced agranulocytosis is a rare but life-threatening condition that requires immediate medical intervention. Although sulbactam/ampicillin (SBT/ABPC) is a widely used antibiotic, no prior case reports of its associated agranulocytosis were identified in our narrative literature review. We present a case of an 85-year-old man who developed agranulocytosis following SBT/ABPC treatment for pressure ulcer infection and aspiration pneumonia, accompanied by a narrative literature review. Awareness of this condition, prompt discontinuation of the suspected agent, and close monitoring of total white blood cell counts are essential for early detection and management of this life-threatening complication.

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Publication Details

Journal
Journal of General and Family Medicine
Published
2025-04-29
DOI
https://doi.org/10.1002/jgf2.70027
Citations
1
Primary Topic
Blood disorders and treatments
Type
article
Field-Weighted Citation Impact
1.82
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article

A case of idiosyncratic drug‐induced agranulocytosis because of sulbactam/ampicillin

Kaku Kuroda, Moe Kuroda, Kota Kawai, Yukihiro Sato et al.
1 citations
Journal of General and Family Medicine
Blood disorders and treatments
1.82
article

A case of idiosyncratic drug‐induced agranulocytosis because of sulbactam/ampicillin

Kaku Kuroda, Moe Kuroda, Kota Kawai, Yukihiro Sato, K Toda
article en
1 citations

Abstract

Idiosyncratic drug-induced agranulocytosis is a rare but life-threatening condition that requires immediate medical intervention. Although sulbactam/ampicillin (SBT/ABPC) is a widely used antibiotic, no prior case reports of its associated agranulocytosis were identified in our narrative literature review. We present a case of an 85-year-old man who developed agranulocytosis following SBT/ABPC treatment for pressure ulcer infection and aspiration pneumonia, accompanied by a narrative literature review. Awareness of this condition, prompt discontinuation of the suspected agent, and close monitoring of total white blood cell counts are essential for early detection and management of this life-threatening complication.

Journal of General and Family MedicineVol. 26(5)
SUNY Upstate Medical University (US), Kamiichi General Hospital (JP), Toyama University Hospital (JP), University of Toyama (JP), University of Rochester (US)
Openalex Percentile: Top 16%
Blood disorders and treatments
1.82
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A case of idiosyncratic drug‐induced agranulocytosis because of sulbactam/ampicillin — Kaku Kuroda, Moe Kuroda, et al. · Journal of General and Family Medicine (2025) | TGRS Research Map | TGRS