Homocysteine stimulates orbital fibroblast proliferation and migration in Graves' orbitopathy via activating Akt signaling pathway
This study supports the potential role of Hcy as a novel biomarker for GO progression. Furthermore, Hcy stimulates OFs proliferation and migration, suggesting its potential as a therapeutic target for GO treatment.
Authors
- Rongrong Xie (ORCID: https://orcid.org/0000-0003-0305-4752)
- Xin Zhong (ORCID: https://orcid.org/0000-0002-6840-1922)
- Tingting Shi (ORCID: https://orcid.org/0000-0002-7008-9229)
- Xi Cao (ORCID: https://orcid.org/0009-0005-4314-4957)
- Zhijia Hou
- Xinyu Xu (ORCID: https://orcid.org/0000-0001-7328-5156)
- Weili Yang (ORCID: https://orcid.org/0000-0003-3646-7772)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.bbrc.2025.151890
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality