Neutrophil Z Is a Novel Marker to Differentiate Disease Flares From Bacterial Infections in Febrile <scp>SLE</scp> Patients
Neutrophil Z, complement C3, anti-dsDNA antibody levels, and TLC or procalcitonin-based composite score are good tools to differentiate between infection and flare in a febrile lupus patient. Serum MRP 8/14, IL-6, sCD14, and nCD64 did not perform well. Simple biomarkers such as neut-Z should be investigated further in SLE.
Authors
- Komal Singh
- M. Gayathri
- Deepika Kounassegarane (ORCID: https://orcid.org/0000-0002-8123-7514)
- Kishan Majithiya (ORCID: https://orcid.org/0009-0009-3192-6088)
- Amita Aggarwal (ORCID: https://orcid.org/0000-0002-2187-5186)
- Chengappa Kavadichanda (ORCID: https://orcid.org/0000-0002-3643-3989)
- Ranjan Gupta (ORCID: https://orcid.org/0000-0003-3965-5410)
- Pankti Mehta (ORCID: https://orcid.org/0000-0001-9134-0999)
- Able Lawrence (ORCID: https://orcid.org/0000-0003-3439-8048)
- Seema Sharma (ORCID: https://orcid.org/0000-0002-9030-0482)
Institutions
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
- Jawaharlal Institute of Post Graduate Medical Education and Research (IN)
- All India Institute of Medical Sciences (IN)
Publication Details
- Journal
- International Journal of Rheumatic Diseases
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1111/1756-185x.70243
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Biotechnology, Ministry of Science and Technology, India