Causal relationship between body mass index and insulin resistance: Linear and nonlinear Mendelian randomization study in a Japanese population
Our findings demonstrated that obesity and low BMI may contribute to increased insulin resistance. Furthermore, the impact of BMI on insulin resistance could vary owing to effect modification. Managing BMI is crucial in individuals at high risk of increased insulin resistance and may have important implications for preventing type 2 diabetes, especially given the low insulin secretory capacity observed in East Asian populations.
Authors
- Aya Hirata (ORCID: https://orcid.org/0000-0003-1439-4242)
- Yasunori Sato (ORCID: https://orcid.org/0000-0002-7189-5126)
- Gen Tamiya
- Kengo Kinoshita (ORCID: https://orcid.org/0000-0003-3453-2171)
- Hirokazu Muraoka
- Kengo Nagashima (ORCID: https://orcid.org/0000-0003-4529-9045)
- Suzuka Kato (ORCID: https://orcid.org/0000-0002-0049-0033)
- Mika Sakurai‐Yageta (ORCID: https://orcid.org/0000-0001-5606-3324)
- Toru Takebayashi (ORCID: https://orcid.org/0000-0002-8268-8026)
- Sei Harada (ORCID: https://orcid.org/0000-0003-2666-4932)
- Naoko Miyagawa (ORCID: https://orcid.org/0000-0002-9148-1078)
- Kazuharu Arakawa (ORCID: https://orcid.org/0000-0002-2893-4919)
- Takuma Shibuki
- Minako Matsumoto (ORCID: https://orcid.org/0000-0002-7705-9903)
- Noriyuki Ishida (ORCID: https://orcid.org/0000-0003-2826-6567)
- Miho Iida
- Ryota Toki
- Shun Edagawa
- Atsuko Miyake
- Kazuyo Kuwabara
Institutions
- Tokyo Medical and Dental University (JP)
- Tama Art University (JP)
- Tohoku University (JP)
- Keio University (JP)
- Keio University Hospital (JP)
- RIKEN Center for Advanced Intelligence Project (JP)
- Tohoku Medical Megabank Organization (JP)
- Keio University Shonan Fujisawa (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Journal of Diabetes Investigation
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1111/jdi.14377
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- Program on Open Innovation Platform with Enterprises, Research Institute and Academia