5-Fluorouracil Impairs Transmission of Acetylcholine in the Hippocampus and Induces Cognitive Impairments in Mice
5-FU therapy caused cognitive impairments in mice by affecting the neuronal structure and activity of ChAT neurons in the MS. Inducing the increase of ACh levels could be a promising therapeutic approach for addressing 5-FU treatment-induced cognitive impairments.
Authors
- Yongquan Lan (ORCID: https://orcid.org/0009-0008-7311-8540)
- Wenjun Chen (ORCID: https://orcid.org/0000-0002-9397-3594)
- Shunqing Peng
- Jianlin Wu (ORCID: https://orcid.org/0009-0002-6739-5484)
- Xiwen Huang (ORCID: https://orcid.org/0000-0002-6874-2241)
Institutions
- Meizhou City People's Hospital (CN)
Publication Details
- Journal
- Journal of Integrative Neuroscience
- Published
- 2025-04-18
- DOI
- https://doi.org/10.31083/jin26903
- Citations
- 1
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province