NELFCD Promotes Colon Cancer Progression by Regulating the DUSP2–p38 Axis
This study suggests that NELFCD promotes the progression of colon cancer by recruiting PRMT5 to inhibit DUSP2 expression, which subsequently activates the p38 signaling pathway. Targeting the NELFCD-DUSP2-p38 signaling axis may be a promising therapeutic intervention for patients suffering from NELFCD-amplified tumors.
Authors
- Baohong Xu (ORCID: https://orcid.org/0000-0003-0755-8819)
- Min Zhu (ORCID: https://orcid.org/0000-0002-7468-0083)
- Haiyun Shi (ORCID: https://orcid.org/0000-0001-5793-1138)
- Peng Li (ORCID: https://orcid.org/0000-0003-2927-2758)
- Yujing Sun (ORCID: https://orcid.org/0000-0002-8077-8060)
- Weiwei Dai
- Guorong Ma
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Luhe Hospital Affiliated to Capital Medical University (CN)
- Peking University International Hospital (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-04-25
- DOI
- https://doi.org/10.31083/fbl25221
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China