XLOC_015548 Mitigates Skeletal Muscle Atrophy via the Gadd45g/MEK/ERK Pathway and Redox Regulation
XLOC_015548 plays a critical role in promoting myogenic differentiation and protecting against muscle atrophy by regulating Gadd45g expression, activating the MEK/ERK signaling pathway, and reducing oxidative stress. These findings underscore the therapeutic potential of XLOC_015548 in skeletal muscle atrophy, and provide a foundation for lncRNA-based treatment strategies.
Authors
- Peng Liu (ORCID: https://orcid.org/0000-0002-8002-9705)
- Haotian Qin (ORCID: https://orcid.org/0000-0001-8898-921X)
- Tiantian Qi (ORCID: https://orcid.org/0000-0002-7521-9168)
- Hui Zeng (ORCID: https://orcid.org/0000-0001-6966-0769)
- Jian Weng (ORCID: https://orcid.org/0000-0001-9262-4993)
- Zimeng Zhou
- Fei Yu (ORCID: https://orcid.org/0000-0002-5941-6452)
- Yingqi Chen (ORCID: https://orcid.org/0009-0004-8897-0104)
Institutions
- Shenzhen University (CN)
- Peking University Shenzhen Hospital (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-04-22
- DOI
- https://doi.org/10.31083/fbl36233
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Sanming Project of Medicine in Shenzhen
- Basic and Applied Basic Research Foundation of Guangdong Province