High-LET Proton Irradiation Significantly Alters the Clonogenic and Tumorigenic Potential of Human Breast Cancer Cell Lines In Vitro and In Vivo
PBI triggers various cellular responses in different BC cell lines, influencing tumor growth through mechanisms like DNA damage repair, stress-induced premature senescence (SIPS), and alterations in the stiffness of tumor cell membranes. Our insights into entosis and the effect of extracellular matrix stiffness on metastatic propensity (nanoparticle uptake) enhance the understanding of the role of PBI in BC cells, emphasizing the need for more research to optimize its therapeutic application.
Authors
- В. О. Сабуров (ORCID: https://orcid.org/0000-0002-6907-2753)
- Margarita V. Pustovalova (ORCID: https://orcid.org/0000-0002-5580-0553)
- Andreyan Nikolaevich Osipov (ORCID: https://orcid.org/0000-0001-5921-9056)
- D V Kolesov (ORCID: https://orcid.org/0000-0003-0270-2893)
- Victor Nekrasov
- Philipp Malakhov (ORCID: https://orcid.org/0009-0005-9901-9362)
- Rita Mohammad (ORCID: https://orcid.org/0000-0002-9528-0636)
- Zain Nofal (ORCID: https://orcid.org/0000-0003-4901-2160)
- Elizaveta Kontareva (ORCID: https://orcid.org/0009-0006-5403-6916)
- Sergey V. Leonov (ORCID: https://orcid.org/0000-0002-3425-723X)
- Yuzhe Wang (ORCID: https://orcid.org/0000-0002-6343-2033)
- Wenyu Xue (ORCID: https://orcid.org/0000-0003-2520-2218)
Institutions
- Ministry of Health of the Russian Federation (RU)
- Medical Radiological Research Center (RU)
- Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences (RU)
- Institute of Cell Biophysics (RU)
- Federal Medical-Biological Agency (RU)
- Moscow Polytechnic University (RU)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-04-25
- DOI
- https://doi.org/10.31083/fbl36415
- Citations
- 8
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.86
Funders
- Ministry of Science and Higher Education of the Russian Federation