MgATPase Activity is Dispensable for the Pharmacological Regulation of the Functional Effects of the KATP Channels Opening in Brain Mitochondria
Brain mKATP channel exhibited high sensitivity to DZ on the low sub-micromolar scale; its regulation by DZ and Glb did not require a MgATPase activity; the impact of DZ on the mPTP activity was critically dependent on the regulation of ROS production by ATP-sensitive K<sup>+</sup> transport.
Authors
- Akopova Ov (ORCID: https://orcid.org/0000-0002-0928-5087)
- Anton Smirnov (ORCID: https://orcid.org/0000-0001-7611-2699)
Institutions
- Bogomoletz Institute of Physiology (UA)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-04-25
- DOI
- https://doi.org/10.31083/fbl33450
- Citations
- 1
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.47