Cross-Species Multi-Omics Analysis Reveals Myeloid-Driven Endothelial Oxidative Stress in Ischemic Stroke
These multi-omics findings highlight the existence of a coordinated peripheral-central immune axis in ischemic stroke, wherein myeloid cell recruitment and endothelial metabolic vulnerability jointly exacerbate inflammation and oxidative stress. The targeting of endothelial oxidative injury and myeloid-endothelial crosstalk may represent a promising strategy to mitigate secondary brain injury in ischemic stroke.
Authors
- Hua Zhu (ORCID: https://orcid.org/0000-0002-3878-2672)
- Feng Shi (ORCID: https://orcid.org/0000-0002-0904-1648)
- Xiaoxing Xiong (ORCID: https://orcid.org/0000-0001-6983-8547)
- Yonggang Zhang (ORCID: https://orcid.org/0009-0005-7815-0097)
- Ziqi Cheng (ORCID: https://orcid.org/0000-0001-7519-7301)
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2025-04-16
- DOI
- https://doi.org/10.31083/fbl37429
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Natural Science Foundation of China