Prevalence of CYP2C9 and VKORC1 polymorphism carriage in patients of the Chuvash population receiving warfarin

Warfarin is an anticoagulant with proven efficacy in preventing thromboembolic complications in patients with mechanical heart valves. Genetic characteristics of the patient, such as carriage of polymorphisms responsible for its pharmacokinetics (CYP2C9) and pharmacodynamics (VKORC1) are significant when selecting doses of this drug.

Authors

Publication Details

Journal
Glavvrač (Chief Medical Officer)
Published
2025-03-22
DOI
https://doi.org/10.33920/med-03-2504-06
Primary Topic
Eicosanoids and Hypertension Pharmacology
Type
article
Field-Weighted Citation Impact
0.00
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article

Prevalence of CYP2C9 and VKORC1 polymorphism carriage in patients of the Chuvash population receiving warfarin

С. И. Павлова, K Georgieva
Glavvrač (Chief Medical Officer)
Eicosanoids and Hypertension Pharmacology
article

Prevalence of CYP2C9 and VKORC1 polymorphism carriage in patients of the Chuvash population receiving warfarin

С. И. Павлова, K Georgieva
article en

Abstract

Warfarin is an anticoagulant with proven efficacy in preventing thromboembolic complications in patients with mechanical heart valves. Genetic characteristics of the patient, such as carriage of polymorphisms responsible for its pharmacokinetics (CYP2C9) and pharmacodynamics (VKORC1) are significant when selecting doses of this drug.

Glavvrač (Chief Medical Officer)(4)
Openalex Percentile: Top 90%
Eicosanoids and Hypertension Pharmacology
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Prevalence of CYP2C9 and VKORC1 polymorphism carriage in patients of the Chuvash population receiving warfarin — С. И. Павлова, K Georgieva · Glavvrač (Chief Medical Officer) (2025) | TGRS Research Map | TGRS