Studying the efficacy of low-intensity laser blood irradiation for microcirculation disorders on the background of obstructive jaundice

Obstructive jaundice is a clinical syndrome that occurs due to a violation of the outflow of bile. In conditions of obstructive jaundice, vasodilation is activated, which causes deterioration of the microcirculatory system and reduces tissue hypoxia. Thus, the analysis of microcirculation changes in obstructive jaundice is a key point in understanding pathophysiological processes, which opens up new horizons for possible therapeutic methods. The purpose is to study the effects of low-intensity laser blood irradiation on microcirculatory changes in patients with obstructive jaundice. Materials and methods: The study analyzed microcirculatory parameters in patients with mild (first and second groups) and severe (third and fourth groups) obstructive jaundice against the background of low-intensity laser blood irradiation and standard therapy. The classification is based on the level of total bilirubin: mild – up to 100 mmol/L, severe – more than 200 mmol/L. The norm values were determined in 15 healthy volunteers. The observation was carried out on days 1, 3, 7, and 9. Low-intensity laser blood irradiation consisted of daily sessions for 9 days. The procedure lasted 15 minutes in the cubital vein projection and 5 minutes in the projection area of the common carotid and vertebral arteries on each side. The Matrix device with a CLOZ head, which emits light with a wavelength of 635 nm and a power of 2MW, was utilized. The method of laser Doppler flowmetry was employed to assess microcirculatory changes. The study was conducted using the laser blood microcirculation analyzer LAKK-2 at the active point E-36 against the background of therapy. Results and discussion: According to the analysis of microcirculatory changes, an excess of normal values was noted during the entire follow-up period in patients with mild and severe obstructive jaundice. These data emphasize the importance of monitoring microcirculation parameters during treatment to assess the dynamics of the disease and the effectiveness of therapeutic measures. Conclusions: A comparative analysis of the conducted studies makes it possible to assess the degree of microcirculation disorders in patients with obstructive jaundice. The data presented above indicate a beneficial effect of laser therapy on microcirculation. It should be noted that in cases of mild and severe obstructive jaundice, low-intensity laser blood irradiation helps to reduce the severity of microcirculation disorders.