Relationship between exhaled volatile organic compounds and lung function change in idiopathic pulmonary fibrosis

Volatile organic compounds (VOCs) in exhaled breath have shown promise as biomarkers in idiopathic pulmonary fibrosis (IPF). We analysed breath from 57 people with IPF using thermal desorption-gas chromatography-mass spectrometry to identify VOCs related to lung function change over 12 months. A LASSO regression model selected 63 VOCs associated with relative change in forced vital capacity (8 with correlation coefficient (CC) ≥0.20 on Spearman's rank analysis), and 28 associated with relative change in diffusion capacity of the lung for carbon monoxide % predicted (12 with CC ≥0.20). Secondary analyses demonstrated a correlation between VOCs and baseline lung function parameters and association with survival. This study suggests that there may be a volatile signature of prognosis in IPF that merits further validation.

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Publication Details

Journal
Thorax
Published
2025-04-29
DOI
https://doi.org/10.1136/thorax-2024-222321
Citations
1
Primary Topic
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Type
article
Field-Weighted Citation Impact
1.52

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article

Relationship between exhaled volatile organic compounds and lung function change in idiopathic pulmonary fibrosis

Dayle Terrington, Stephen James Fowler, Nazia Chaudhuri, Waqar Ahmed et al.
1 citations
Thorax
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
1.52
article

Relationship between exhaled volatile organic compounds and lung function change in idiopathic pulmonary fibrosis

Dayle Terrington, Stephen James Fowler, Nazia Chaudhuri, Waqar Ahmed, Iain R. White, Conal Hayton, Andrew M. Wilson, Colm Leonard
article en
1 citations

Abstract

Volatile organic compounds (VOCs) in exhaled breath have shown promise as biomarkers in idiopathic pulmonary fibrosis (IPF). We analysed breath from 57 people with IPF using thermal desorption-gas chromatography-mass spectrometry to identify VOCs related to lung function change over 12 months. A LASSO regression model selected 63 VOCs associated with relative change in forced vital capacity (8 with correlation coefficient (CC) ≥0.20 on Spearman's rank analysis), and 28 associated with relative change in diffusion capacity of the lung for carbon monoxide % predicted (12 with CC ≥0.20). Secondary analyses demonstrated a correlation between VOCs and baseline lung function parameters and association with survival. This study suggests that there may be a volatile signature of prognosis in IPF that merits further validation.

ThoraxVol. 80(8)
University of East Anglia (GB), University of Ulster (GB), University of Nova Gorica (SI), Manchester Academic Health Science Centre (GB), Norfolk and Norwich University Hospitals NHS Foundation Trust (GB), Manchester University NHS Foundation Trust (GB), Western Health and Social Care Trust (GB), NIHR Manchester Biomedical Research Centre (GB)
Boehringer Ingelheim, Carrick Therapeutics
Openalex Percentile: Top 19%
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
1.52
DOIOpen Access PDFOpenAlex
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