Evaluation Of Serum Level Of Pentraxin 3 As A Biomarker For Prediction Of Gestational Diabetes Mellitus

Background: Gestational diabetes mellitus is associated with adverse perinatal outcome. Screening for gestational diabetes mellitus and applying adequate interventions may reduce the risk of adverse outcome. However, the diagnosis of gestational diabetes mellitus depends largely on test performed in late second trimester. The discovery of new biomarker buildup a simple model to predict gestational diabetes mellitus in early pregnancy one of them is Pentraxin 3. Objective: In this study we aimed, to evaluate the potential relationship between Pentraxin 3 and occurrence of gestational diabetes at 24-28 weeks of gestation and to evaluate the significance of Pentraxin 3 as early predictor of gestational diabetes. Study design: prospective case-control study. Setting: Department of Obstetrics and Gynecology, Al-Yarmouk Teaching Hospital, Baghdad / Iraq. Patient and methods: The study involved 150 pregnant women with singleton pregnancy, 75 of them with risk factors for gestational diabetes mellitus as a case group( group 1) and the other group have no risk factor as a control group (group 2) Each participant was given an appointment at 14-18 weeks of gestation .Blood sample was taken from all after fasting for 8 –hours. Unfortunately, we missed a lot of them. However Pentraxin 3 concentration, fasting plasma glucose, glycosylated hemoglobin and fasting plasma insulin were all tested and analyzed subsequently to those who continue the study. Furthermore, there was another appointment at 24—28 weeks of gestation for 75 g OGTT. Results: Pentraxin 3 was significantly higher in participants of Group (1) who had risk factors (p-value=0.01) .And there is significant association between high body mass index and gestational diabetes mellitus of a p-value 0.05. Oral glucose tolerance test was significantly higher on first, second and third readings in Group (1) who had risk factor (p value were 0.028, 0.05 and 0.01 respectively). Conclusion: Serum Pentraxin 3 level was significantly higher in patient with gestational diabetes mellitus, The increase in oral glucose tolerance test was significant associated with an increase in the PTX-3. Keywords : gestational diabetes mellitus, biomarkers, pregnancy