Comparative vasorelaxant effects of atorvastatin and rosuvastatin in rat aorta:investigating the role of perivascular adipose tissue
The current study demonstrated that atorvastatin and rosuvastatin displayed prominent relaxations in rat aortic rings with intact PVAT (+) and without PVAT (-). Notably, rosuvastatin produced a greater vasorelaxant effect compared to atorvastatin in rat aortic rings with and without PVAT. Current study provides a novel evidence that PVAT does not significantly influence statin-mediated vasorelaxation under physiological conditions.
Authors
- Ramazan Sami Aktaş (ORCID: https://orcid.org/0000-0002-6671-4239)
- Birsel Sönmez Uydeş Doğan (ORCID: https://orcid.org/0000-0002-6729-8150)
- Deniz Kalelі Durman (ORCID: https://orcid.org/0000-0002-8669-7480)
- M Aras (ORCID: https://orcid.org/0000-0002-5926-0953)
Institutions
- Biruni University (TR)
- Istanbul University (TR)
Publication Details
- Journal
- TURKISH JOURNAL OF MEDICAL SCIENCES
- Published
- 2025-04-17
- DOI
- https://doi.org/10.55730/1300-0144.5996
- Citations
- 1
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 1.39