Physiological effects of aqueous pomegranate peel extract on hematological, liver and lipid profiles in moderately obese men

This study evaluates the therapeutic potential of Pomegranate Peel Extract (PPE) in 104 individuals over a 12-week period. A total of 66 moderately obese participants (groups 4, 5 and 6) received 2000 mg of PPE, while 38 healthy individuals (groups 1, 2 and 3) received 1500 mg, with and without adherence to a healthy diet. Hematological indices [Red Blood Cell (RBC) and White Blood Cell (WBC) count, platelet (PLT), haemoglobin (HGB) levels and hematocrit (HCT) percentages], biochemical markers [glucose, lipid profiles - Total Cholesterol (TC), triglycerides (TG) and Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL)] and liver enzymes - Aspartate aminotransferase (AST), Alanine Aminotransferase (ALT before and after the study period. Additionally, body mass index (BMI), systolic and diastolic blood pressure recorded. Results showed significant increases in HGB, PLT, WBC and HDL levels particularly in moderately obese individuals who consume PPE alongside a healthy diet (group 6). This group also exhibited notable reductions in glucose, TC, TG, LDL, ALT, AST, BMI, systolic and diastolic blood pressure. These results suggest that PPE may serve as a promising natural intervention for managing obesity and improving metabolic health due to its anti-glycemic, hepatoprotective, cardio-protective, weight management and metabolic regulation effects. However, further clinical studies are required to determine optimal dosages and long-term effects across diverse populations.