Cytochrome P450 2E1 aggravates DXR-induced myocardial injury through imbalanced mitochondrial OPA1
CYP2E1 disrupts OPA1-mediated mitochondrial dynamics, causing mitochondrial fragmentation and apoptosis, which aggravate myocardial injury. Targeting CYP2E1 may offer a therapeutic strategy to mitigate myocardial damage, particularly in chemotherapeutic drug-induced cardiotoxicity.
Authors
- Jiaxin Ma
- Dan Lü (ORCID: https://orcid.org/0000-0002-5204-2574)
- Huanchang Lv (ORCID: https://orcid.org/0009-0009-4791-9667)
- Feifei Guan (ORCID: https://orcid.org/0000-0003-3421-2768)
- Yu Lei
- He Wang (ORCID: https://orcid.org/0000-0001-6561-9777)
- Lianfeng Zhang (ORCID: https://orcid.org/0000-0002-5774-2924)
- Yaheng Wang
- Wei Dong (ORCID: https://orcid.org/0000-0002-5945-8126)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Jiaotong University (CN)
- Institute of Laboratory Animal Science (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1186/s12964-025-02197-w
- Citations
- 2
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 2.33