Lactate-induced macrophage HMGB1 lactylation promotes neutrophil extracellular trap formation in sepsis-associated acute kidney injury
This study revealed that lactate-induced HMGB1 lactylation in macrophages plays a role in promoting NET formation in SAKI through the cGAS/STING pathway. These findings suggest that HMGB1 could be a potential target for therapeutic intervention in SAKI.
Authors
- Lei Wu (ORCID: https://orcid.org/0000-0002-0818-7338)
- Zili Dai (ORCID: https://orcid.org/0000-0001-7982-2258)
- Zhen Xiang (ORCID: https://orcid.org/0000-0002-4284-2041)
- Zhen Du (ORCID: https://orcid.org/0000-0002-5882-1595)
- Siwei Wei (ORCID: https://orcid.org/0000-0003-1718-9981)
- Xiaoxiao Yang
- Liubing Jiang
Institutions
- Fourth Hospital of Changsha (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2025-04-30
- DOI
- https://doi.org/10.1007/s10565-025-10026-6
- Citations
- 22
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 17.54