Pd-Catalyzed Regioselective Hydroxymethylation of Olefins with HCO<sub>2</sub>H via Sequential Hydroformylation and Reduction
An effective Pd-catalyzed regioselective hydroxymethylation of olefins with HCO<sub>2</sub>H and Ac<sub>2</sub>O is described. A variety of primary alcohols can be obtained in up to 94% yield and a >20:1 l:b ratio via sequential hydroformylation and reduction. The reaction is operationally simple with no need for external CO and H<sub>2</sub>.
Authors
- Wenlong Ren (ORCID: https://orcid.org/0000-0002-2028-4667)
- Yian Shi (ORCID: https://orcid.org/0000-0001-9016-2078)
- Ke Huang (ORCID: https://orcid.org/0000-0003-4832-9692)
- Jinzi Huang
- Yuan Shi (ORCID: https://orcid.org/0009-0009-8491-3838)
- Xujian Sheng
- Jintao Ou
Institutions
- Catalytic Materials (United States) (US)
- Changzhou University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-29
- DOI
- https://doi.org/10.1021/acs.joc.5c00436
- Citations
- 1
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Changzhou University